Best for · energy
Energy & Wakefulness
Acute energy boosts (caffeine, modafinil) sit alongside mitochondrial support (CoQ10, ALCAR, creatine, NR/NMN). The strongest stacks blend immediate stimulation with cellular ATP production for energy that lasts past noon.
Ranked substances
| # | Substance | Category | Typical dose | Evidence | Safety | In stacks |
|---|---|---|---|---|---|---|
| 1 | Caffeine | stimulant | 50–400mg | EVIDENCEA | ●●●●○ | 5 |
| 2 | L-Tyrosine | amino-acid | 500–2000mg | EVIDENCEA | ●●●●● | 3 |
| 3 | B-Complex | vitamin | 50–150mg | EVIDENCEA | ●●●●● | 2 |
| 4 | CoQ10 | neuroprotective | 100–300mg | EVIDENCEA | ●●●●● | 2 |
| 5 | Creatine | amino-acid | 3000–5000mg | EVIDENCEA | ●●●●● | 2 |
| 6 | Melatonin | neuroprotective | 0.3–3mg | EVIDENCEA | ●●●●● | 2 |
| 7 | Magnesium Glycinate | neuroprotective | 200–400mg | EVIDENCEB | ●●●●● | 2 |
| 8 | Alpha-GPC | cholinergic | 300–600mg | EVIDENCEA | ●●●●● | 1 |
| 9 | L-Theanine | amino-acid | 100–400mg | EVIDENCEA | ●●●●● | 1 |
| 10 | Nicotinamide Riboside (NR) | neuroprotective | 250–1000mg | EVIDENCEA | ●●●●● | 1 |
| 11 | Alpha-Lipoic Acid | neuroprotective | 300–600mg | EVIDENCEA | ●●●●○ | 1 |
| 12 | Modafinil | stimulant | 100–200mg | EVIDENCEA | ●●●○○ | 1 |
Curated stacks for energy
All-Day Energy Stack
Sustainable energy without afternoon crash. Mitochondrial cofactors + balanced stimulant.
Cognitive Pre-Workout
Pre-workout that doubles as a cognitive stack. Vasodilation + dopamine + focus.
Hangover Recovery Stack
Morning-after cognitive rescue. Antioxidants, electrolytes, ALCAR, and B vitamins.
Jet Lag Stack
Short-term circadian re-entrainment for travel. Don't use indefinitely.
Mitochondrial Energy Stack
Deep cellular energy support. Targets NAD+, mitochondrial biogenesis, and ATP buffering.
Shift Worker Stack
Cognitive support and circadian recovery for shift work. Acute alertness + structured sleep recovery.
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