neuroprotectiveEVIDENCEAUSOTC
Alpha-Lipoic Acid
aka ALA · Thioctic acid
Universal antioxidant active in both lipid and aqueous environments. Supports mitochondrial function and AGE reduction.
Dose range300–600mg
Half-life1h
Onset—min
Safety4/5high evidence base
Mechanism of action
Antioxidant active in both lipid and aqueous environments. Regenerates other antioxidants (C, E, glutathione). Improves insulin sensitivity.
Benefits
Diabetic neuropathy
EVIDENCEAALADIN trials.
Insulin sensitivity
EVIDENCEBMultiple RCTs.
Side effects
- Hypoglycemia (combined w insulin)uncommonmoderate
- GI upsetcommonmild
Where to buy
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