Stacking guide
What goes well with Modafinil?
Evidence-graded stacking partners for Modafinil. Synergistic and neutral combinations are listed alongside pairings to avoid. Use this to design a deliberate stack rather than experimenting blind.
Safe to stack with Modafinil (1)
- L-TyrosineEVIDENCEA
Amino acid precursor to dopamine, norepinephrine, and epinephrine. Effective for cognitive performance under stress.
L-Tyrosine supports DA precursor; complements modafinil's DA reuptake inhibition.
Combine with caution (3)
- CaffeineEVIDENCEA
The most widely consumed psychoactive substance in human history — roughly 80% of the global population uses it daily, mostly via coffee and tea. A competitive adenosine receptor antagonist that lifts the brake on dopamine and norepinephrine signalling. The canonical pairing is 100 mg caffeine + 200 mg L-theanine for clean focus without the jitter.
Dual strong stimulants — afternoon insomnia, anxiety, elevated HR. Drop caffeine after 11am if combining.
- MethylphenidateEVIDENCEA
Prescription stimulant for ADHD (Ritalin, Concerta). Increases dopamine and norepinephrine.
Both increase DA/NE. Manageable under physician supervision; risky DIY.
- Amphetamine (Adderall)EVIDENCEA
Prescription stimulant combination (Adderall) for ADHD and narcolepsy. Stronger than methylphenidate.
Both elevate DA. Manageable under MD; cardiovascular monitoring advised.
Avoid stacking (4)
- PhenylpiracetamEVIDENCEB
A phenylated derivative of piracetam 20-60x more potent. Originally developed for Soviet cosmonauts.
Two strong dopaminergic stimulants — high overstimulation and cardiovascular risk.
- ArmodafinilEVIDENCEA
The R-enantiomer of modafinil. Similar effects with smoother onset and longer duration per dose.
Duplicate compounds — armodafinil IS the R-isomer of modafinil. Pick one.
- AdrafinilEVIDENCEB
Prodrug of modafinil. Converted in the liver. Used historically before modafinil was widely available.
Adrafinil is a modafinil prodrug — taking both stacks the active metabolite.
- YohimbineEVIDENCEB
Alkaloid from Pausinystalia yohimbe bark. Alpha-2 adrenergic antagonist. Increases norepinephrine. Used for fat loss, libido, and acute focus.
Anxiety / panic risk. Don't combine.
Build a stack: use the Stack Builder with Modafinil pre-selected, or check any specific pairing in the Interaction Checker.
Stacking guidance reflects curated interaction rules from the published literature, traditional use, and well-characterised mechanisms. Individual response varies; introduce one substance at a time and track effects. Not medical advice — see our disclaimer.