Comparison
Melatonin vs Urolithin A (Mitopure)
Melatonin
Pineal hormone regulating circadian rhythm. Low doses (0.3-1mg) often outperform higher doses for sleep.
Urolithin A (Mitopure)
Bioactive metabolite of pomegranate ellagitannins. Direct mitophagy activator. The supplement form bypasses the gut microbiome variability.
| Field | Melatonin | Urolithin A (Mitopure) |
|---|---|---|
| Category | neuroprotective | neuroprotective |
| Dose range | 0.3–3mg | 500–1000mg |
| Half-life | 1h | — |
| Onset | 30min | — |
| Evidence | EVIDENCEA | EVIDENCEB |
| Safety | ●●●●● | ●●●●● |
| Legal (US) | USOTC | USOTC |
| PubMed refs | 28000 | 280 |
The comparison in plain English
Auto-generated from dataMelatonin and Urolithin A (Mitopure) are both in the neuroprotective category respectively. Melatonin Pineal hormone regulating circadian rhythm. Urolithin A (Mitopure) Bioactive metabolite of pomegranate ellagitannins.
Bottom line
Melatonin (evidence A, safety 5/5) has a weaker evidence base than Urolithin A (Mitopure) (evidence B, safety 5/5). Melatonin has the slightly cleaner safety profile. For users new to either, the higher-evidence option is the safer first try.
Choose Melatonin if
Melatonin is the better fit when your goal aligns with its mechanism (Endogenous hormone produced by the pineal gland in response to darkness, signalling the circadian sleep window) and the dose range (0.3–3mg) suits your protocol. Half-life is 1h.
Choose Urolithin A (Mitopure) if
Urolithin A (Mitopure) is the better fit when your goal aligns with its mechanism (Selectively activates mitophagy — the autophagy of damaged mitochondria — through PINK1/Parkin signaling) and the dose range (500–1000mg) suits your protocol. Half-life is —h.