Comparison
Melatonin vs Krill Oil
Melatonin
Pineal hormone regulating circadian rhythm. Low doses (0.3-1mg) often outperform higher doses for sleep.
Krill Oil
Phospholipid-bound omega-3 from Antarctic krill. Contains EPA and DHA in phospholipid form (more bioavailable than triglyceride fish oil) plus astaxanthin.
| Field | Melatonin | Krill Oil |
|---|---|---|
| Category | neuroprotective | neuroprotective |
| Dose range | 0.3–3mg | 500–2000mg |
| Half-life | 1h | — |
| Onset | 30min | — |
| Evidence | EVIDENCEA | EVIDENCEB |
| Safety | ●●●●● | ●●●●○ |
| Legal (US) | USOTC | USOTC |
| PubMed refs | 28000 | 380 |
The comparison in plain English
Auto-generated from dataMelatonin and Krill Oil are both in the neuroprotective category respectively. Melatonin Pineal hormone regulating circadian rhythm. Krill Oil Phospholipid-bound omega-3 from Antarctic krill.
Bottom line
Melatonin (evidence A, safety 5/5) has a weaker evidence base than Krill Oil (evidence B, safety 4/5). Melatonin has the slightly cleaner safety profile. For users new to either, the higher-evidence option is the safer first try.
Choose Melatonin if
Melatonin is the better fit when your goal aligns with its mechanism (Endogenous hormone produced by the pineal gland in response to darkness, signalling the circadian sleep window) and the dose range (0.3–3mg) suits your protocol. Half-life is 1h.
Choose Krill Oil if
Krill Oil is the better fit when your goal aligns with its mechanism (Krill oil delivers omega-3 fatty acids (EPA and DHA) bound to phospholipids rather than triglycerides) and the dose range (500–2000mg) suits your protocol. Half-life is —h.