neuroprotectiveEVIDENCEBUSOTC

Krill Oil

aka Antarctic krill oil

Phospholipid-bound omega-3 from Antarctic krill. Contains EPA and DHA in phospholipid form (more bioavailable than triglyceride fish oil) plus astaxanthin.

Dose range500–2000mg

Half-life—h

Onset—min

Safety4/5medium evidence base

Mechanism of action

Krill oil delivers omega-3 fatty acids (EPA and DHA) bound to phospholipids rather than triglycerides. The phospholipid form is more readily absorbed and incorporated into cell membranes; small doses of krill produce blood EPA/DHA equivalent to larger doses of standard fish oil. Includes naturally-occurring astaxanthin, which both supports the omega-3 stability and provides independent antioxidant activity.

History

Krill oil emerged as a commercial supplement in the late 2000s with sustainability concerns (Antarctic krill is the base of the Southern Ocean food web) initially limiting adoption. Sustainability certifications from organisations like MSC reduced these concerns. The bioavailability advantage over standard fish oil has been demonstrated in multiple studies. Pricing is typically 2-3x standard fish oil per gram of EPA+DHA.

Benefits

Cardiovascular markers
EVIDENCEB
Multiple RCTs.
Joint inflammation
EVIDENCEB
Suzuki 2015.
Premenstrual symptoms
EVIDENCEB
Sampalis 2003.

Side effects

Shellfish allergy contraindicationraresevere
Fishy aftertaste (rare)uncommonmild

Cited research

Krill oil vs fish oil bioavailability (Schuchardt)2011
PMID 21854650 ↗
Krill oil and arthritis: clinical trial (Suzuki)2015
PMID 25789021 ↗
Krill oil for premenstrual syndrome (Sampalis)2003
PMID 12777161 ↗

Where to buy

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Vendor	Product	Size	Price	Per unit
Nootropics DepotFeatured 4.8	Krill Oil — Nootropics Depot	—	See vendor	—	Shop Ad
Life Extension 4.3	Krill Oil — Life Extension	—	See vendor	—	Shop Ad
Double Wood Supplements 4.4	Krill Oil — Double Wood	—	See vendor	—	Shop Ad
Amazon Marketplace 3.5	Krill Oil — Amazon	—	See vendor	—	Shop Ad

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