Comparison
Melatonin vs Hesperidin
Melatonin
Pineal hormone regulating circadian rhythm. Low doses (0.3-1mg) often outperform higher doses for sleep.
Hesperidin
Citrus flavonoid found in oranges and lemons. Cardiovascular protection and neuroprotection. The 2S enantiomer is bioactive.
| Field | Melatonin | Hesperidin |
|---|---|---|
| Category | neuroprotective | neuroprotective |
| Dose range | 0.3–3mg | 250–1000mg |
| Half-life | 1h | — |
| Onset | 30min | — |
| Evidence | EVIDENCEA | EVIDENCEB |
| Safety | ●●●●● | ●●●●● |
| Legal (US) | USOTC | USOTC |
| PubMed refs | 28000 | 2200 |
The comparison in plain English
Auto-generated from dataMelatonin and Hesperidin are both in the neuroprotective category respectively. Melatonin Pineal hormone regulating circadian rhythm. Hesperidin Citrus flavonoid found in oranges and lemons.
Bottom line
Melatonin (evidence A, safety 5/5) has a weaker evidence base than Hesperidin (evidence B, safety 5/5). Melatonin has the slightly cleaner safety profile. For users new to either, the higher-evidence option is the safer first try.
Choose Melatonin if
Melatonin is the better fit when your goal aligns with its mechanism (Endogenous hormone produced by the pineal gland in response to darkness, signalling the circadian sleep window) and the dose range (0.3–3mg) suits your protocol. Half-life is 1h.
Choose Hesperidin if
Hesperidin is the better fit when your goal aligns with its mechanism (Flavanone glycoside with antioxidant activity) and the dose range (250–1000mg) suits your protocol. Half-life is —h.