neuroprotectiveEVIDENCEBUSOTC

Hesperidin

aka Hesperidin methyl chalcone

Citrus flavonoid found in oranges and lemons. Cardiovascular protection and neuroprotection. The 2S enantiomer is bioactive.

Dose range250–1000mg

Half-life—h

Onset—min

Safety5/5medium evidence base

Mechanism of action

Flavanone glycoside with antioxidant activity. Modulates endothelial function through eNOS upregulation. Anti-inflammatory through NF-κB suppression. Crosses BBB and has direct neuroprotective effects in animal models. The free aglycone (hesperetin) is the active form after gut metabolism.

History

Hesperidin was isolated from orange peel in 1828. Its cardiovascular effects have been studied extensively in European clinical research. Multiple meta-analyses support blood pressure and lipid effects. Modern interest extends to cognitive and neuroprotective applications. Unscheduled globally.

Benefits

Vascular function (endothelial)
EVIDENCEB
Multiple meta-analyses.
Blood pressure reduction
EVIDENCEB
Multiple trials.
Neuroprotection (animal models)
EVIDENCEC
Multiple animal studies.

Side effects

Mild GI upsetraremild

Cited research

Hesperidin for cardiovascular function: meta-analysis (Salden)2018
PMID 29222403 ↗
Hesperidin and brain protection (Hwang)2012
PMID 23207193 ↗
Hesperidin bioavailability and metabolism (Bredsdorff)2010
PMID 20162320 ↗

Where to buy

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Vendor	Product	Size	Price	Per unit
Nootropics DepotFeatured 4.8	Hesperidin — Nootropics Depot	—	See vendor	—	Shop Ad
Life Extension 4.3	Hesperidin — Life Extension	—	See vendor	—	Shop Ad
Double Wood Supplements 4.4	Hesperidin — Double Wood	—	See vendor	—	Shop Ad
Amazon Marketplace 3.5	Hesperidin — Amazon	—	See vendor	—	Shop Ad

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