Comparison
Melatonin vs Fisetin
Melatonin
Pineal hormone regulating circadian rhythm. Low doses (0.3-1mg) often outperform higher doses for sleep.
Fisetin
Flavonoid found in strawberries. Senolytic — selectively clears senescent cells. Promising longevity intervention.
| Field | Melatonin | Fisetin |
|---|---|---|
| Category | neuroprotective | neuroprotective |
| Dose range | 0.3–3mg | 100–500mg |
| Half-life | 1h | — |
| Onset | 30min | — |
| Evidence | EVIDENCEA | EVIDENCEB |
| Safety | ●●●●● | ●●●●○ |
| Legal (US) | USOTC | USOTC |
| PubMed refs | 28000 | 1700 |
The comparison in plain English
Auto-generated from dataMelatonin and Fisetin are both in the neuroprotective category respectively. Melatonin Pineal hormone regulating circadian rhythm. Fisetin Flavonoid found in strawberries.
Bottom line
Melatonin (evidence A, safety 5/5) has a weaker evidence base than Fisetin (evidence B, safety 4/5). Melatonin has the slightly cleaner safety profile. For users new to either, the higher-evidence option is the safer first try.
Choose Melatonin if
Melatonin is the better fit when your goal aligns with its mechanism (Endogenous hormone produced by the pineal gland in response to darkness, signalling the circadian sleep window) and the dose range (0.3–3mg) suits your protocol. Half-life is 1h.
Choose Fisetin if
Fisetin is the better fit when your goal aligns with its mechanism (Senolytic activity — selectively induces apoptosis in senescent cells (cells that have stopped dividing but remain metabolically active and inflammatory)) and the dose range (100–500mg) suits your protocol. Half-life is —h.