Comparison
Magnesium L-Threonate vs Urolithin A (Mitopure)
Magnesium L-Threonate
MIT-developed magnesium that crosses the blood-brain barrier. Shown to enhance synaptic density and reduce 'brain age'.
Urolithin A (Mitopure)
Bioactive metabolite of pomegranate ellagitannins. Direct mitophagy activator. The supplement form bypasses the gut microbiome variability.
| Field | Magnesium L-Threonate | Urolithin A (Mitopure) |
|---|---|---|
| Category | neuroprotective | neuroprotective |
| Dose range | 1000–2000mg | 500–1000mg |
| Half-life | 6h | — |
| Onset | — | — |
| Evidence | EVIDENCEB | EVIDENCEB |
| Safety | ●●●●● | ●●●●● |
| Legal (US) | USOTC | USOTC |
| PubMed refs | 90 | 280 |
The comparison in plain English
Auto-generated from dataMagnesium L-Threonate and Urolithin A (Mitopure) are both in the neuroprotective category respectively. Magnesium L-Threonate MIT-developed magnesium that crosses the blood-brain barrier. Urolithin A (Mitopure) Bioactive metabolite of pomegranate ellagitannins.
Bottom line
Magnesium L-Threonate (evidence B, safety 5/5) matches the evidence base of Urolithin A (Mitopure) (evidence B, safety 5/5). Magnesium L-Threonate has the slightly cleaner safety profile. For users new to either, the higher-evidence option is the safer first try.
Choose Magnesium L-Threonate if
Magnesium L-Threonate is the better fit when your goal aligns with its mechanism (L-threonate is a sugar-acid carrier that uniquely enables magnesium to cross the blood-brain barrier in meaningful quantities — most oral magnesium forms (oxide, citrate, glycinate) raise serum magnesium but not central magnesium) and the dose range (1000–2000mg) suits your protocol. Half-life is 6h.
Choose Urolithin A (Mitopure) if
Urolithin A (Mitopure) is the better fit when your goal aligns with its mechanism (Selectively activates mitophagy — the autophagy of damaged mitochondria — through PINK1/Parkin signaling) and the dose range (500–1000mg) suits your protocol. Half-life is —h.