vitaminEVIDENCEAUSOTC
Vitamin D3
aka Cholecalciferol
Hormone-like vitamin synthesized in skin from UVB. Profoundly involved in brain function, mood, and inflammation.
Dose range0.025–0.125mg
Half-life360h
Onset—min
Safety5/5high evidence base
Mechanism of action
Binds VDR in brain. Modulates neurotrophic factors, dopamine, and inflammation. Most adults are deficient.
Benefits
Mood / mild depression
EVIDENCEBSpedding 2014 meta-analysis (high-quality subset).
Cognitive function in deficient elderly
EVIDENCEBMultiple RCTs.
Immune function
EVIDENCEAUniversally accepted.
Side effects
- Hypercalcemia (very high dose)raresevere
Where to buy
Affiliate links| Vendor | Product | Size | Price | Per unit | |
|---|---|---|---|---|---|
| Double Wood Supplements 4.4 | Vitamin D3 + K2, 180ct | 180 | $14.99 | $0.08 | Buy |