vitaminEVIDENCEBUSOTC
Vitamin B6 (P5P)
aka Pyridoxine · P5P · Pyridoxal-5-Phosphate
Pyridoxal-5-phosphate (P5P) is the active form. Cofactor in 140+ enzymes including neurotransmitter synthesis.
Dose range10–50mg
Half-life—h
Onset—min
Safety4/5high evidence base
Mechanism of action
Cofactor for decarboxylase, transaminase, and dehydratase reactions including dopamine, serotonin, and GABA synthesis.
Benefits
PMS symptoms
EVIDENCEBWyatt 1999 meta-analysis.
Cognitive function in deficient elderly
EVIDENCEBMultiple RCTs.
Side effects
- Sensory neuropathy (chronic high dose)raresevere
Where to buy
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