neuroprotectiveEVIDENCEAUSRx
Rapamycin
aka Sirolimus
mTOR inhibitor approved for immunosuppression after organ transplant. Studied off-label for longevity at low intermittent doses.
Dose range5–10mg
Half-life—h
Onset—min
Safety2/5high evidence base
Mechanism of action
Selective inhibitor of mTORC1. Reduces protein synthesis, induces autophagy. Pulsed dosing minimizes immunosuppression.
Benefits
Lifespan extension in mice
EVIDENCEAMultiple replicated studies.
Immune system rejuvenation
EVIDENCEBMannick 2014.
Side effects
- Immunosuppressioncommonsevere
- Mouth ulcerscommonmoderate
- Hyperlipidemiacommonmoderate
- Glucose intolerancecommonmoderate
Where to buy
Affiliate linksNo vendor products listed yet. Vendors — list a product.