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neuroprotectiveEVIDENCEBUSOTC

Pomegranate Extract

aka Punica granatum

Standardised extract rich in punicalagins. Cardiovascular and cognitive benefits; metabolised to urolithins by gut bacteria.

Dose range250–1000mg
Half-life—h
Onset—min
Safety5/5medium evidence base

Mechanism of action

Punicalagins and other ellagitannins are metabolised by gut bacteria to urolithin A and related compounds. Urolithin A is the proximal mediator of mitochondrial benefit — Mitopure (synthetic urolithin A) is a purified version. Direct antioxidant activity. Endothelial function support. Anti-inflammatory through NF-κB suppression.

History

Pomegranate has been used in Middle Eastern, Mediterranean, and Indian traditional medicine for millennia. Modern interest accelerated with the identification of urolithin A as the bioactive metabolite. Multiple cardiovascular trials support arterial health benefits. The urolithin A direct supplementation (Mitopure from Amazentis) emerged in the 2020s.

Benefits

  • Cardiovascular function (arterial stiffness)

    EVIDENCEB

    Aviram 2004.

  • Cognitive function (small trials)

    EVIDENCEC

    Bookheimer 2013.

  • Erectile function

    EVIDENCEC

    Forest 2007.

Side effects

  • Mild GI upsetraremild

Cited research

Where to buy

Affiliate links

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VendorProductSizePricePer unit
Nootropics DepotFeatured 4.8Pomegranate Extract — Nootropics Depot—See vendor—Shop Ad
Life Extension 4.3Pomegranate Extract — Life Extension—See vendor—Shop Ad
Double Wood Supplements 4.4Pomegranate Extract — Double Wood—See vendor—Shop Ad
Amazon Marketplace 3.5Pomegranate Extract — Amazon—See vendor—Shop Ad

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