racetamEVIDENCEAUSUnscheduled
Piracetam
aka Nootropil · Lucetam · Breinox
The original nootropic, developed in 1964 by Romanian chemist Corneliu Giurgea. A cyclic derivative of GABA and the founding member of the racetam family.
Dose range1200–4800mg
Half-life5h
Onset45min
Safety5/5high evidence base
Mechanism of action
Modulates AMPA and NMDA glutamate receptors and enhances acetylcholine signaling via muscarinic receptor allosteric modulation. Improves membrane fluidity.
Benefits
Verbal learning and memory
EVIDENCEAMeta-analysis of 19 double-blind trials.
Cognitive function in elderly
EVIDENCEBImprovement in patients with cognitive decline.
Neuroprotection
EVIDENCEBEffects during oxygen deprivation.
Side effects
- Headachecommonmild
- GI discomfortuncommonmild
Where to buy
Affiliate links| Vendor | Product | Size | Price | Per unit | |
|---|---|---|---|---|---|
| Nootropics DepotFeatured 4.8 | Piracetam Powder, 125g | — | $17.99 | — | Buy |
| Pure Nootropics 4.5 | Piracetam Capsules, 90ct (500mg) | 90 × 500mg | $25.99 | $0.29 | Buy |