Picamilon
aka N-nicotinoyl-GABA · Nicotinyl gamma-aminobutyric acid
Russian-developed compound combining niacin and GABA. Crosses the blood-brain barrier (which standard GABA cannot) and provides combined cerebrovascular and GABAergic effects.
Mechanism of action
Hybrid molecule of niacin and GABA. Crosses the blood-brain barrier (unlike standard GABA) and then cleaves into the constituent compounds in brain tissue. Niacin produces mild cerebrovascular vasodilation; GABA produces direct inhibitory neurotransmitter activity. The combination produces calming effect with cognitive support.
History
Picamilon was developed in the Soviet Union in the 1960s at the Russian Academy of Medical Sciences as a treatment for cerebrovascular disorders and anxiety. It's used as a prescription drug in Russia and several former Soviet states. The FDA classified it as not a legal dietary supplement in 2015, limiting availability in the US. It remains unscheduled in most other jurisdictions.
Benefits
Anxiolytic effect
EVIDENCECRussian clinical use.
Cerebrovascular function
EVIDENCECRussian clinical trials in stroke recovery.
Side effects
- Mild headachecommonmild
- GI upsetuncommonmild
Cited research
- Picamilon Russian clinical literature: review (Mirzoyan)1989PMID 1842437 ↗
- Picamilon as GABA prodrug: mechanism (Dorofeev)1996PMID 8967036 ↗
Where to buy
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| Vendor | Product | Size | Price | Per unit | |
|---|---|---|---|---|---|
| Double Wood Supplements 4.4 | Picamilon — Double Wood | — | See vendor | — | Shop Ad |
| BulkSupplements 4.2 | Picamilon — BulkSupplements | — | See vendor | — | Shop Ad |
| NOW Foods 4.1 | Picamilon — NOW Foods | — | See vendor | — | Shop Ad |
| Amazon Marketplace 3.5 | Picamilon — Amazon | — | See vendor | — | Shop Ad |
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