research_chemicalEVIDENCECUSResearch chemicalBanned: US (not a legal supplement), AU, UK PSA 2016
Phenibut
Russian GABA-B agonist. Anxiolytic and sleep-promoting, but with significant dependence risk. Banned as a supplement in the US/AU.
Dose range250–1000mg
Half-life5h
Onset120min
Safety1/5low evidence base
Mechanism of action
GABA-B agonist (like baclofen). Some GABA-A activity. Long half-life and rebound rebound anxiety on discontinuation.
Benefits
Acute anxiolytic / social anxiety
EVIDENCECRussian clinical use.
Side effects
- Severe dependence/withdrawalcommonsevere
- Tolerance within days of regular usecommonmoderate
- Sedationcommonmoderate
Where to buy
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