Pantogam (Hopantenic Acid)
aka Calcium hopantenate · D-Pantoyl-GABA · Calcium homopantothenate
Russian prescription nootropic combining pantothenic acid (B5) and GABA. Used for ADHD, anxiety, and pediatric cognitive disorders in Russia.
Mechanism of action
A hybrid molecule of pantothenic acid (vitamin B5) and GABA. Provides GABAergic effects without the BBB-crossing problem of standard GABA. The pantothenic acid moiety supports coenzyme A synthesis and acetylcholine production.
History
Pantogam was developed in the Soviet Union in the 1970s and is approved as a prescription drug in Russia for ADHD, anxiety, sleep disorders, and pediatric cognitive conditions. It's unscheduled or in regulatory grey area in most Western jurisdictions. The Russian clinical literature is substantial but largely untranslated; Western evidence is sparse.
Benefits
Pediatric ADHD/cognitive disorders
EVIDENCECRussian clinical use.
Anxiety
EVIDENCECRussian clinical trials.
Side effects
- Mild GI upsetuncommonmild
Cited research
- Pantogam for cognitive disorders in children (Russian literature)2009PMID 20088200 ↗
- Hopantenic acid pharmacology review1994PMID 8042521 ↗
Where to buy
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| Vendor | Product | Size | Price | Per unit | |
|---|---|---|---|---|---|
| Double Wood Supplements 4.4 | Pantogam (Hopantenic Acid) — Double Wood | — | See vendor | — | Shop Ad |
| BulkSupplements 4.2 | Pantogam (Hopantenic Acid) — BulkSupplements | — | See vendor | — | Shop Ad |
| NOW Foods 4.1 | Pantogam (Hopantenic Acid) — NOW Foods | — | See vendor | — | Shop Ad |
| Amazon Marketplace 3.5 | Pantogam (Hopantenic Acid) — Amazon | — | See vendor | — | Shop Ad |
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