racetamEVIDENCEBUSUnscheduled
Nefiracetam
Fat-soluble racetam developed in Japan with GABAergic anxiolytic + cholinergic memory effects.
Dose range150–450mg
Half-life4h
Onset—min
Safety3/5medium evidence base
Mechanism of action
Enhances NMDA and nicotinic ACh receptor function. Mild GABAergic potentiation. Increases long-term potentiation.
Benefits
Memory and learning
EVIDENCEBAnimal models; Japanese clinical trials.
Apathy in post-stroke patients
EVIDENCEBRobinson 2009.
Side effects
- Hepatotoxicity at high dose in animalsraremoderate
Where to buy
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