adaptogenEVIDENCEBUSOTC
Kanna
aka Sceletium tortuosum · Zembrin
Sceletium tortuosum — South African succulent. Acts as serotonin reuptake inhibitor and PDE4 inhibitor.
Dose range25–50mg
Half-life—h
Onset—min
Safety3/5medium evidence base
Mechanism of action
Mesembrine and related alkaloids inhibit serotonin reuptake and PDE4. Mild anxiolytic + mood-elevating.
Benefits
Anxiety and mood
EVIDENCEBChiu 2014.
Cognitive flexibility
EVIDENCEBDimpfel 2018.
Side effects
- Headacheuncommonmild
- Avoid with SSRIscommonsevere
Where to buy
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