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He Shou Wu (Fo-Ti)

aka Polygonum multiflorum · Fo-Ti · Foti

Chinese herb (Polygonum multiflorum) traditionally used for longevity and hair pigmentation. Hepatotoxicity concerns with processed vs raw forms.

Dose range500–2000mg
Half-life—h
Onset—min
Safety2/5low evidence base

Mechanism of action

Anthraquinones, stilbenes, and phospholipids contribute to antioxidant and lipid-lowering effects. Animal studies show neuroprotection and modest cognitive enhancement. The mechanism for hair pigmentation claim is unclear and the evidence is weak.

History

He Shou Wu has been used in Traditional Chinese Medicine for centuries. Significant hepatotoxicity has been documented with raw, unprocessed root and with high doses. The processed form (steamed with black bean) is much safer; the raw form should be avoided. Some commercial products mix raw and processed, producing variable safety profiles. Cases of acute liver failure have occurred.

Benefits

  • Cardiovascular markers

    EVIDENCEC

    Multiple Chinese trials.

  • Hair pigmentation (claimed; weak evidence)

    EVIDENCED

    Traditional use only.

Side effects

  • Hepatotoxicity (raw form)uncommonsevere
  • Acute liver failure (rare)raresevere

Cited research

Where to buy

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VendorProductSizePricePer unit
Nootropics DepotFeatured 4.8He Shou Wu (Fo-Ti) — Nootropics Depot—See vendor—Shop Ad
Double Wood Supplements 4.4He Shou Wu (Fo-Ti) — Double Wood—See vendor—Shop Ad
Amazon Marketplace 3.5He Shou Wu (Fo-Ti) — Amazon—See vendor—Shop Ad
iHerb 4.2He Shou Wu (Fo-Ti) — iHerb—See vendor—Shop Ad

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