vitaminEVIDENCEBUSOTC
Folate (Methylfolate)
aka L-methylfolate · 5-MTHF · Metafolin
L-methylfolate is the active form bypassing MTHFR polymorphisms. Critical for methylation and monoamine synthesis.
Dose range0.4–7.5mg
Half-life—h
Onset—min
Safety5/5high evidence base
Mechanism of action
Methyl donor for methionine synthase and downstream methylation reactions. Required for monoamine neurotransmitter synthesis.
Benefits
Depression (especially treatment-resistant)
EVIDENCEBPapakostas 2014.
Cognitive function in elderly
EVIDENCEBMultiple RCTs.
Side effects
- Insomnia if dosed lateuncommonmild
Where to buy
Affiliate linksNo vendor products listed yet. Vendors — list a product.