neuroprotectiveEVIDENCEBUSOTC
Curcumin (Turmeric)
aka Diferuloylmethane · Meriva · Theracurmin
Yellow pigment of turmeric root. Powerful anti-inflammatory with cognitive and mood benefits.
Dose range500–2000mg
Half-life—h
Onset—min
Safety5/5high evidence base
Mechanism of action
Inhibits NF-κB. Reduces neuroinflammation. Promotes BDNF. Bioavailability requires piperine, phospholipid (Meriva), or nano-particle form.
Benefits
Memory and attention
EVIDENCEBSmall 2018 RCT.
Depression
EVIDENCEBNg 2017 meta-analysis.
Joint inflammation
EVIDENCEAMultiple RCTs.
Side effects
- Mild blood thinninguncommonmild
- GI upset (high dose)uncommonmild
Where to buy
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