adaptogenEVIDENCEAUSOTC
Ashwagandha
aka Withania somnifera · KSM-66 · Sensoril
Indian ginseng (Withania somnifera) — premier adaptogen for stress, anxiety, sleep, and testosterone in men.
Dose range300–600mg
Half-life6h
Onset—min
Safety5/5high evidence base
Mechanism of action
Withanolides modulate GABA-A receptors and HPA axis. Reduces cortisol. Antioxidant effects on hippocampus.
Benefits
Cortisol reduction (~28%)
EVIDENCEAMultiple RCTs, KSM-66 studied most.
Anxiety reduction
EVIDENCEAPratte et al. 2014 meta-analysis.
Sleep quality
EVIDENCEBSalve et al. 2019.
Testosterone in men
EVIDENCEBLopresti et al. 2019.
Side effects
- Drowsinesscommonmild
- GI upsetuncommonmild
Where to buy
Affiliate links| Vendor | Product | Size | Price | Per unit | |
|---|---|---|---|---|---|
| Nootropics DepotFeatured 4.8 | KSM-66 Ashwagandha Capsules, 60ct (600mg) | 60 × 600mg | $24.99 | $0.42 | Buy |
| Double Wood Supplements 4.4 | KSM-66 Ashwagandha, 90ct (600mg) | 90 × 600mg | $19.99 | $0.22 | Buy |