cholinergicEVIDENCEBUSOTC
Acetyl-L-Carnitine (ALCAR)
aka ALCAR · ALC
Acetylated form of L-carnitine that crosses the BBB. Donates an acetyl group for ACh synthesis and supports mitochondrial fatty-acid transport.
Dose range500–2000mg
Half-life4h
Onset60min
Safety5/5high evidence base
Mechanism of action
Acetyl group precursor for acetylcholine. Facilitates fatty acid transport into mitochondria for ATP production. Antioxidant via glutathione support.
Benefits
Cognitive function in mild cognitive impairment
EVIDENCEBMultiple RCTs, meta-analysis.
Reduced mental fatigue
EVIDENCEBMalaguarnera et al. 2008.
Side effects
- Fishy body odoruncommonmild
- GI upsetraremild
Where to buy
Affiliate links| Vendor | Product | Size | Price | Per unit | |
|---|---|---|---|---|---|
| Nootropics DepotFeatured 4.8 | Acetyl-L-Carnitine (ALCAR) Capsules, 60ct (500mg) | 60 × 500mg | $17.99 | $0.30 | Buy |
| Double Wood Supplements 4.4 | Acetyl L-Carnitine, 150ct (500mg) | 150 × 500mg | $17.99 | $0.12 | Buy |