amino-acidEVIDENCEBUSOTC
5-HTP
Direct serotonin precursor, one step closer than tryptophan. Sourced from Griffonia simplicifolia seeds.
Dose range50–200mg
Half-life2h
Onset—min
Safety3/5medium evidence base
Mechanism of action
Direct precursor to serotonin (and downstream melatonin). Crosses BBB.
Benefits
Mood / depression support
EVIDENCEBOlder RCTs.
Sleep onset
EVIDENCEBSmall RCTs.
Side effects
- Nauseacommonmoderate
- Risk with SSRIs (serotonin syndrome)uncommonsevere
Where to buy
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