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Stacking guide

What goes well with Melatonin?

Evidence-graded stacking partners for Melatonin. Synergistic and neutral combinations are listed alongside pairings to avoid. Use this to design a deliberate stack rather than experimenting blind.

Safe to stack with Melatonin (1)

  • Magnesium L-ThreonateEVIDENCEB

    MIT-developed magnesium that crosses the blood-brain barrier. Shown to enhance synaptic density and reduce 'brain age'.

    Common sleep stack. Start melatonin low (0.3-1mg).

Combine with caution (1)

  • Valerian RootEVIDENCEB

    Herbal sedative used for centuries for insomnia and anxiety. Acts via GABA pathway.

    Both sedating. Watch for morning grogginess.

Build a stack: use the Stack Builder with Melatonin pre-selected, or check any specific pairing in the Interaction Checker.

Stacking guidance reflects curated interaction rules from the published literature, traditional use, and well-characterised mechanisms. Individual response varies; introduce one substance at a time and track effects. Not medical advice — see our disclaimer.