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Stacking guide

What goes well with Magnesium L-Threonate?

Evidence-graded stacking partners for Magnesium L-Threonate. Synergistic and neutral combinations are listed alongside pairings to avoid. Use this to design a deliberate stack rather than experimenting blind.

Safe to stack with Magnesium L-Threonate (3)

  • L-TheanineEVIDENCEA

    An amino acid found almost exclusively in tea leaves. Promotes relaxed alertness via alpha-wave promotion and GABA/serotonin/dopamine modulation. Pairs with caffeine in a 1:2 ratio to produce the most-validated focus synergy in the nootropic literature. Essentially no side-effect or interaction profile at typical doses.

    Classic sleep pairing — magnesium calms NMDA, L-theanine raises alpha.

  • ApigeninEVIDENCEB

    Flavonoid found in chamomile, parsley, and celery. Popularized by Dr. Andrew Huberman for sleep and CD38 inhibition.

    Huberman sleep stack staple.

  • MelatoninEVIDENCEA

    Pineal hormone regulating circadian rhythm. Low doses (0.3-1mg) often outperform higher doses for sleep.

    Common sleep stack. Start melatonin low (0.3-1mg).

Build a stack: use the Stack Builder with Magnesium L-Threonate pre-selected, or check any specific pairing in the Interaction Checker.

Stacking guidance reflects curated interaction rules from the published literature, traditional use, and well-characterised mechanisms. Individual response varies; introduce one substance at a time and track effects. Not medical advice — see our disclaimer.