Stacking guide
What goes well with Creatine?
Evidence-graded stacking partners for Creatine. Synergistic and neutral combinations are listed alongside pairings to avoid. Use this to design a deliberate stack rather than experimenting blind.
Safe to stack with Creatine (2)
- CaffeineEVIDENCEA
The most widely consumed psychoactive substance in human history — roughly 80% of the global population uses it daily, mostly via coffee and tea. A competitive adenosine receptor antagonist that lifts the brake on dopamine and norepinephrine signalling. The canonical pairing is 100 mg caffeine + 200 mg L-theanine for clean focus without the jitter.
Older data suggested antagonism — newer studies show no issue.
- L-TheanineEVIDENCEA
An amino acid found almost exclusively in tea leaves. Promotes relaxed alertness via alpha-wave promotion and GABA/serotonin/dopamine modulation. Pairs with caffeine in a 1:2 ratio to produce the most-validated focus synergy in the nootropic literature. Essentially no side-effect or interaction profile at typical doses.
No known interaction.
Build a stack: use the Stack Builder with Creatine pre-selected, or check any specific pairing in the Interaction Checker.
Stacking guidance reflects curated interaction rules from the published literature, traditional use, and well-characterised mechanisms. Individual response varies; introduce one substance at a time and track effects. Not medical advice — see our disclaimer.