nootropics.com
SubstancesStacksToolsCompareVendorsGuidesBuild a stack
Back to Amphetamine (Adderall)

Stacking guide

What goes well with Amphetamine (Adderall)?

Evidence-graded stacking partners for Amphetamine (Adderall). Synergistic and neutral combinations are listed alongside pairings to avoid. Use this to design a deliberate stack rather than experimenting blind.

Combine with caution (1)

  • ModafinilEVIDENCEA

    A eugeroic — a wakefulness-promoting compound — originally developed for narcolepsy. The most-studied prescription cognitive enhancer outside of ADHD treatment. Produces 12–15 hour windows of sustained alertness without the euphoria, abuse potential, or cardiovascular load of amphetamines. Prescription-only in nearly every jurisdiction.

    Both elevate DA. Manageable under MD; cardiovascular monitoring advised.

Avoid stacking (1)

  • MethylphenidateEVIDENCEA

    Prescription stimulant for ADHD (Ritalin, Concerta). Increases dopamine and norepinephrine.

    Duplicate prescription stimulants — switch, don't stack.

Build a stack: use the Stack Builder with Amphetamine (Adderall) pre-selected, or check any specific pairing in the Interaction Checker.

Stacking guidance reflects curated interaction rules from the published literature, traditional use, and well-characterised mechanisms. Individual response varies; introduce one substance at a time and track effects. Not medical advice — see our disclaimer.