Comparison
Noopept vs Dihexa
Noopept
Russian-developed proline-containing dipeptide ~1000x more potent than piracetam by weight. Often grouped with racetams.
Dihexa
Hexapeptide ~7 orders of magnitude more potent than BDNF in promoting synaptogenesis. Extensive animal data; no human trials.
| Field | Noopept | Dihexa |
|---|---|---|
| Category | peptide | peptide |
| Dose range | 10–30mg | 5–35mg |
| Half-life | 0.5h | — |
| Onset | 20min | — |
| Evidence | EVIDENCEB | EVIDENCEC |
| Safety | ●●●●○ | ●○○○○ |
| Legal (US) | USUnscheduled | USResearch chemical |
| PubMed refs | 90 | 25 |
The comparison in plain English
Auto-generated from dataNoopept and Dihexa are both in the peptide category respectively. Noopept Russian-developed proline-containing dipeptide ~1000x more potent than piracetam by weight. Dihexa Hexapeptide ~7 orders of magnitude more potent than BDNF in promoting synaptogenesis.
Bottom line
Noopept (evidence B, safety 4/5) has a weaker evidence base than Dihexa (evidence C, safety 1/5). Noopept has the slightly cleaner safety profile. For users new to either, the higher-evidence option is the safer first try.
Choose Noopept if
Noopept is the better fit when your goal aligns with its mechanism (Increases BDNF and NGF expression in the hippocampus and prefrontal cortex) and the dose range (10–30mg) suits your protocol. Half-life is 0.5h.
Choose Dihexa if
Dihexa is the better fit when your goal aligns with its mechanism (Activates the hepatocyte growth factor (HGF) / Met receptor system in neurons, which promotes dendritic spine formation and synaptogenesis) and the dose range (5–35mg) suits your protocol. Half-life is —h.