Comparison
Modafinil vs Methylphenidate
Modafinil
Eugeroic developed for narcolepsy; one of the most popular prescription cognitive enhancers. Sustained alertness without traditional stimulant side effects.
Methylphenidate
Prescription stimulant for ADHD (Ritalin, Concerta). Increases dopamine and norepinephrine.
| Field | Modafinil | Methylphenidate |
|---|---|---|
| Category | stimulant | stimulant |
| Dose range | 100–200mg | 5–40mg |
| Half-life | 14h | 3h |
| Onset | 45min | 30min |
| Evidence | EVIDENCEA | EVIDENCEA |
| Safety | ●●●○○ | ●●●○○ |
| Legal (US) | USSchedule IV | USSchedule II |
| PubMed refs | 3200 | 7800 |
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