Comparison
Melatonin vs Resveratrol
Melatonin
Pineal hormone regulating circadian rhythm. Low doses (0.3-1mg) often outperform higher doses for sleep.
Resveratrol
Polyphenol from grape skins and Japanese knotweed. SIRT1 activator. Studied for longevity and cardiovascular health.
| Field | Melatonin | Resveratrol |
|---|---|---|
| Category | neuroprotective | neuroprotective |
| Dose range | 0.3–3mg | 250–500mg |
| Half-life | 1h | 9h |
| Onset | 30min | — |
| Evidence | EVIDENCEA | EVIDENCEB |
| Safety | ●●●●● | ●●●●● |
| Legal (US) | USOTC | USOTC |
| PubMed refs | 28000 | 16000 |
The comparison in plain English
Auto-generated from dataMelatonin and Resveratrol are both in the neuroprotective category respectively. Melatonin Pineal hormone regulating circadian rhythm. Resveratrol Polyphenol from grape skins and Japanese knotweed.
Bottom line
Melatonin (evidence A, safety 5/5) has a weaker evidence base than Resveratrol (evidence B, safety 5/5). Melatonin has the slightly cleaner safety profile. For users new to either, the higher-evidence option is the safer first try.
Choose Melatonin if
Melatonin is the better fit when your goal aligns with its mechanism (Endogenous hormone produced by the pineal gland in response to darkness, signalling the circadian sleep window) and the dose range (0.3–3mg) suits your protocol. Half-life is 1h.
Choose Resveratrol if
Resveratrol is the better fit when your goal aligns with its mechanism (Activates SIRT1 (sirtuin 1), the longevity-associated histone deacetylase that mediates calorie restriction's lifespan extension in model organisms) and the dose range (250–500mg) suits your protocol. Half-life is 9h.