Comparison
Alpha-GPC vs Centrophenoxine
Alpha-GPC
The most bioavailable common choline source. About 40% of an oral dose reaches the brain within an hour, where it serves as substrate for acetylcholine synthesis and as a phospholipid membrane component. The de facto pairing for every racetam stack.
Centrophenoxine
Ester of DMAE and 4-chlorophenoxyacetic acid. Anti-aging cholinergic studied for lipofuscin reduction.
| Field | Alpha-GPC | Centrophenoxine |
|---|---|---|
| Category | cholinergic | cholinergic |
| Dose range | 300–600mg | 250–1000mg |
| Half-life | 6h | 4h |
| Onset | 30min | — |
| Evidence | EVIDENCEA | EVIDENCEB |
| Safety | ●●●●● | ●●●●○ |
| Legal (US) | USOTC | USUnscheduled |
| PubMed refs | 320 | 80 |
The comparison in plain English
Auto-generated from dataAlpha-GPC and Centrophenoxine are both in the cholinergic category respectively. Alpha-GPC The most bioavailable common choline source. Centrophenoxine Ester of DMAE and 4-chlorophenoxyacetic acid.
Bottom line
Alpha-GPC (evidence A, safety 5/5) has a weaker evidence base than Centrophenoxine (evidence B, safety 4/5). Alpha-GPC has the slightly cleaner safety profile. For users new to either, the higher-evidence option is the safer first try.
Choose Alpha-GPC if
Alpha-GPC is the better fit when your goal aligns with its mechanism (Rapidly absorbed and cleaved into choline and glycerophosphate) and the dose range (300–600mg) suits your protocol. Half-life is 6h.
Choose Centrophenoxine if
Centrophenoxine is the better fit when your goal aligns with its mechanism (Hydrolysed in vivo to DMAE plus 4-chlorophenoxyacetic acid) and the dose range (250–1000mg) suits your protocol. Half-life is 4h.