Tianeptine Sodium vs Tianeptine Sulfate: Your guide to the Tianeptine Trend

There are usually two major grievances about most antidepressant medications; firstly, that it takes far too long to feel any effects (if at all), and secondly (perhaps more importantly for many of us), they can seriously impair your sex life. 

Tianeptine is an antidepressant with near-immediate mood-boosting effects that won’t mess with your libido, nor is it known for other common side-effects of antidepressants such as interrupted sleep or weight gain. For those interested in the unique range of benefits offered by Tianeptine, one of the first questions asked is which form of the nootropic is best; sodium or sulfate? We’ve provided information in this article that will help you decide which form of Tianeptine is right for you.

What is Tianeptine?

Tianeptine is a novel tricyclic antidepressant that has been gaining in popularity recently due to its fast-acting effects and low risk profile when compared to other antidepressants. It is often described as “atypical” because its unique neurochemical mechanism is not fully understood by researchers. Getting into this involves a lot of complicated chemistry, but if you’re a science nerd like us, we’ve included some resources at the end of this article if you want to learn more about how Tianeptine works on the chemical level. 

The Benefits of Tianeptine

Tianeptine has been shown to be as effective as other mainstream antidepressants for improving low mood, tiredness and brain fog. But unlike most other antidepressants, you don’t have to wait six weeks to feel an improvement. Tianeptine works to produce a subtle but noticeable lift in mood almost immediately and may also have cognitive enhancement effects. Several studies have shown that Tianeptine improves various learning processes such as short-term memory, attention and reaction time, meaning that your ability to process and recall new information is heightened. 

This is why Tianeptine has become popular amongst many people looking for nootropic enhancements, and not just those experiencing depression.

For those suffering from depression however (particularly treatment-resistant depression), Tianeptine could be a game-changer. Described by some mental health researchers as a “potential break-through” in the treatment of depression, Tianeptine is an option for those frustrated with their experience of more mainstream antidepressants, or those who want to see results more quickly.

As mentioned at the beginning of this article, another major benefit of Tianeptine is, of course, that it has been shown to be far less likely to cause sexual dysfunction than other antidepressant medications. Antidepressant-induced sexual dysfunction is a common problem that is often treated as a footnote in the treatment of depression, but can have a significant impact on quality of life. It can put strain on relationships and cause associated feelings of frustration and embarrassment. Tianeptine could well be the answer to this problem for many people. A 2003 study of 23 participants with depression who were experiencing antidepressant-induced sexual dysfunction showed a significant improvement in sexual function after switching to Tianeptine from their previous antidepressant.

Tianeptine Sulfate vs Tianeptine Sodium

Tianeptine is available in two forms; sulfate and sodium. Both forms provide the same beneficial effects, boosting mood and improving focus and memory. The main difference between the two is the way Tianeptine is made available in the body, changing the timing of the effects and the way you experience them. Depending on your needs, one form of Tianeptine may work better for you.

So what’s the difference between these two forms? The quick answer is that Tianeptine sodium provides an immediate boost but doesn’t last very long, while Tianeptine sulfate takes longer to kick in, but provides sustained improvements in mood and focus over time. Read on for more details about how the two forms are metabolized, or skip ahead if you’re ready to try Tianeptine.

Tianeptine sodium: a quick lift

Sodium is a very common additive in a range of medications because it makes them more easily dissolvable after digestion, which aids absorption of the active ingredient(s) into the body. Unlike Tianeptine sulfate, which is bound to a sulfate molecule to slow release, Tianeptine sodium is linked only with weak chemical bonds. This means it is broken down and metabolized rapidly by the body, providing an immediate release and extremely fast-acting effects. The downside is that the effects wear off more quickly, so Tianeptine sodium is great for providing quick short bursts of improved mood and energy, but this feeling won’t be sustained long-term.

Tianeptine sulfate: a subtle but sustained boost

Because Tianeptine sulfate is bound to a sulfate molecule, it needs to first be broken down by the liver before it is released into the body. This process delays the availability of the drug and therefore the effects take longer to kick in (about 2 – 4 hours, which is still lightning-fast compared to most antidepressants) and can feel more subtle. Fans of the sulfate form often describe the effect as feeling “smoother” than Tianeptine sodium. The benefit of this is that the release of the Tianeptine is steady over a longer period of time, providing a subtle but noticeable improvement in mood, concentration and focused energy for your entire day.

On Nootropics.com, you can buy Tianeptine sulfate in capsule form, as this is the most efficient way for us to ensure the accuracy and precision of dosing. The majority of Tianeptine sold online comes in powder form, which means having to mess around with micro-scoops and scales. For convenience and accuracy, each of our capsules contains 25mg of Tianeptine sulfate, which is an ideal dose for a gentle boost in mood and noticeable cognitive effect. Tianeptine is also included in our Mood Lift Stack.

We believe a longer, more sustained release is a healthy ideal that suits most people’s goals with this nootropic. However, Tianeptine sodium can be a suitable choice for those wanting just a few hours of extra energy and improved mood.

Who Should Try Tianeptine?

Though Tianeptine is often prescribed as an antidepressant, you don’t need to be diagnosed with or experiencing depression to benefit from its mood-boosting and cognitive effects. If you are experiencing depression, we strongly recommend that you first speak to your doctor about your treatment options, which will ideally involve a combination of talk therapy and medication. Our Tianeptine capsules should not take the place of your regular prescribed medication, but If you’ve tried various treatments and you’re still looking for something to improve your mood, Tianeptine may indeed work for you.

Drug Interactions

Like most antidepressants, Tianeptine may have some drug interactions. The only confirmed dangerous drug interaction is with Tramadol, a pain-relief medication. Extra care should be taken if you are currently on any other medication. When in doubt, always check with a health professional. 


Tianeptine: the mood-lifting nootropic and antidepressant that can improve your memory, sharpen your focus, and keep your libido going strong. Nootropics.com Tianeptine is verified high-quality, and processed with the utmost precision and integrity. Buy our lab-tested Tianeptine here, or explore our other game-changing nootropics for an enhanced life.

Further Resources

More information on the neurochemical profile of Tianeptine and how it works:

Tianeptine: a novel atypical antidepressant that may provide new insights into the biomolecular basis of depression

The atypical antidepressant and neurorestorative agent tianeptine is a μ-opioid receptor agonist

References used in the article

Effect of tianeptine on cognitive functions in patients with depressive disorders during a 3-month observation
Possible usefulness of Tianeptine in treatment-resistant depression
Switching to tianeptine in patients with antidepressant‐induced sexual dysfunction
The neurobiological properties of Tianeptine (Stablon): from monoamine hypothesis to glutamatergic modulation
Tianeptine: A novel atypical antidepressant that may provide new insights into the biomolecular basis of depression