Sunifiram: A Powerful Nootropic That Delivers Powerful Cognitive Benefits

Have you ever felt buried beneath your work and thought to yourself “if only there were more hours in the day” or “if only I could clone myself,” then, I’d be able to tackle everything that’s on my plate? Sure, that would be helpful. And maybe Sunifiram can help.

Unfortunately, it doesn’t look like we’ll be getting 30-hour days, or an army of clones any time in the foreseeable future.

That’s where nootropics come in.

Nootropics can provide you with a pronounced mental edge in your everyday life. These novel drugs and supplements deliver improvements in areas like learning, memory retention, memory formation, cognition, and executive functioning.

In particular, Sunifiram is one of the most promising nootropics, and many users consider it their secret weapon and the ideal way to boost their cognition, focus, and attention. Today, we’re going to take a closer look at everything you need to know about this powerful nootropic, so you can decide if sunifiram is a good fit for your performance goals.

What is Sunifiram?

Sunifiram is a research chemical which is also known by its developmental codename, DM235. Like many nootropics, this drug is being developed and researched as a potential treatment for different degenerative diseases such as Alzheimer’s, Parkinson’s, and dementia. Sunifiram also appears to be promising as a treatment for attention issues.

Similar to the racetam family of nootropics which all neurohackers are familiar with, sunifiram is significantly more potent. Research suggests that it’s as much as 1,000 times as potent as phenylpiracetam, and 30,000 times as potent as piracetam.

The nootropic community quickly adopted sunifiram as a way to get a cognitive edge in their everyday lives. While much more research is needed to substantiate the potential benefits of sunifiram fully, initial results look promising, and there seems to be a wide range of benefits that this exceptionally powerful nootropic can provide.

What are the benefits of Sunifiram?

Although study on sunifiram has been confined to animal studies and anecdotal evidence, sunifiram users throughout the nootropic community report a broad range of powerful cognitive, focus, and attention-related benefits.

One such study focused on groups of rats and their ability to learn concepts with and without the aid of DM235. The study concluded that the DM235 group learned at a significantly quicker pace than the control group, in spite of an amnesia-inducing agent. This study suggests that DM235 may be able to improve learning, memory formation, and memory retention.

In animal testing, sunifiram also appears to boost levels of Acetylcholine (ACh). ACh is the first neurotransmitter scientists ever discovered, and it plays a key role in cognitive function, memory formation, and recall. Increased levels of ACh may help improve all levels of cognitive function, especially when it comes to memory.

Anecdotal evidence of sunifiram also suggests it may be able to sharpen your visual and aural perception and help you to think more clearly without any of the brain fog that affects virtually all of us. Some users also report that sunifiram enhances pleasure-related experiences. Delicious food seems tastier, music seems even better, and some even report that sex is better, too.

Sunifiram is also incredibly potent, and yet still available at a low price. This translates to an exceptionally low cost per dose, which is ideal for the neurohacker on a budget. While a piracetam user may take as much as 10g per day, a sunifiram dosage is typically 5-10mg. This translates to a price per dose of about a nickel or dime, which is another major sunifiram benefit.

How does Sunifiram work?

As of today, that is the million-dollar question. Scientists have yet to nail down the mechanism of action for this nootropic. With many compounds, it’s clear how they affect different areas of the brain based on how they bind with different receptors. While sunifiram was found around all the brain’s central receptors, it didn’t show a particular affinity towards any of them, even at high doses.

So, while researchers are still unsure how sunifiram produces its effect, there have been anti amnesiac and cognitive-enhancing effects observed in studies, as well as increased ACh levels in the cerebral cortex. These findings alone suggest that sunifiram is certainly worthy of greater research.

Who is Sunifiram best for?

As a powerful cognitive enhancer that’s free of the stimulant effects associated with drugs like Adderall, modafinil, and even racetams, sunifiram is a compelling nootropic for virtually anyone looking to get a mental edge.

Those who work demanding jobs in STEM fields are sure to appreciate the boost to cognitive function that sunifiram can provide. Lawyers, doctors, IT professionals, and other highly skilled workers that continue to study throughout their careers will also benefit greatly from sunifiram.

Of course, students who are looking for an edge with their classwork are also an ideal candidate for giving sunifiram a shot. As sunifiram appears to positively impact executive function as well, virtually anybody with a demanding career or field of study can benefit greatly from sunifiram.

What is Sunifiram similar to?

Sunifiram is a molecularly simplified version of unifiram. When it comes to unifiram vs sunifiram, there isn’t much to differentiate the two, outside of their chemical composition. Both are four orders of magnitude more potent than piracetam, and both produce a similar effect.

Sunifiram is also quite similar to the racetam family of nootropics, and it’s probably most similar to Noopept, which is one of the most beloved cognitive and performance-enhancing nootropics on the market.

Popular Sunifiram stacks

Many nootropics users are looking to optimize the edge they get as much as possible and stack different compounds together in order to unlock the cognitive benefits they’re after.

Perhaps as a result of its molecular closeness, sunifiram is often stacked with a racetam, such as aniracetam or phenylpiracetam. Whenever you’re taking a racetam, and especially if it’s part of a stack, you should also consider adding a supplement to support choline production, like Alpha GPC or centrophenoxine.

5mg Sunifiram
750mg Aniracetam
150mg Alpha GPC

Given the popularity of Noopept, and it’s similarities to sunifiram, these two nootropics are often stacked together as well. As with racetams, it’s important to add a strong source of choline to the stack to prevent headaches.

5mg Sunifiram
30mg Noopept
150mg Alpha GPC

Sunifiram also appears to stack well with L-theanine, which is one of the most popular and well-studied mood-boosting nootropics available. A popular stack combines L-theanine with sunifiram and sulbutiamine.

5mg Sunifiram
200mg L-theanine
200mg Sulbutiamine

How to take Sunifiram

The recommended sunifiram dosage is 5-10mg up to three times daily. Users report that taking the drug sublingually helps improve absorption and the onset of the effects of sunifiram. This nootropic acts quite quickly, and users feel it’s effect within 15-20 minutes of their dose.

As with all nootropics, you should start with the smallest possible dose and work your way up from there. If you’ve never used sunifiram before, start by taking a 2.5mg dose to see how your body reacts to the drug, if at all. From there, you can amp up your dosage as necessary until you’ve found the optimal dosage for you.

With such a small amount of scientific study on sunifiram, it’s a research chemical in the truest sense of the word. If you find that you aren’t experiencing the effects you’re looking for within a typical dosage range, it might be a good idea to look to a different nootropic, as opposed to moving onto higher doses, since we know so little about how it may affect you.

Sunifiram side effects

While initial research suggests that sunifiram is virtually non-toxic and doesn’t produce any notable side effects, it’s important to note how little research has been conducted on this compound. For this reason, it’s incredibly important that you begin with a low dosage before ramping up to a higher one, and pay close attention to any noted side effects you experience.

Based on anecdotal evidence, some sunifiram users have experienced side effects such as:

  • Headache
  • Hot flashes
  • Difficulty sleeping
  • Manic feelings

These side effects seem only to be mentioned with dosages outside of the 5-10mg range, with higher doses producing more pronounced side effects. If you find that you’re experiencing side effects as you up your dosage, ramp down your dosage to a level where no side effects are present.


As one of the most powerful and effective nootropics available, sunifiram is a compelling choice for those looking to achieve a stimulant-free cognitive performance edge. This compound seems to provide a compelling range of benefits, including an exceptionally low cost per dose, making it one of the most affordable nootropics on the market.

It’s important to keep in mind that out of all the nootropics available, this is one that we know very little about from a research perspective. If you’re adding sunifiram to your routine, do so carefully, and discontinue use if you experience any side effects.