Sulbutiamine: A Synthetic Vitamin for Mind and Body

While many nootropics provide benefits that are usually restricted to your brain, Sulbutiamine is unique in the fact that it fortifies both your body and brain. It supports the central nervous system, as well as muscular and digestive systems, and it plays a key role in the flow of electrolytes through our bodies.

Beyond that, there are also powerful nootropic benefits to sulbutiamine, making it a trusted and oft-used tool in many neurohacker’s arsenals.

Today, we’re going to take a closer look at everything you need to know about sulbutiamine, including sulbutiamine dosage, benefits, much more.

What is Sulbutiamine?

Sulbutiamine is a synthetic analog of vitamin B1 (thiamine). Thiamine was the first B vitamin discovered by scientists, hence the B1 moniker. This vitamin plays a key role in many aspects of your overall health, and it’s found in some of your favorite foods.

But thiamine is poorly absorbed, since it has difficulty crossing the blood-brain barrier. Without a proper diet or supplementation, a lack of thiamine can lead to serious health risks.

One such health crisis is how we wound up with sulbutiamine in the first place. During World War II, Japanese soldiers and civilians alike began to develop a deadly disease known as beriberi, which can be caused by a B1 deficiency.

Unfortunately, supplementing with thiamine alone wasn’t enough to treat the illness, thanks to the poor bioavailability of this vitamin. Scientists created a synthetic version of thiamine, which is known as sulbutiamine. By fusing two vitamin B1 molecules together, scientists were able to create a fat-soluble analog to B1, which had greater bioavailability. The health crisis was averted.

So, sulbutiamine is simply two thiamine molecules that are chemically bonded together. Sulbutiamine can more easily pass the blood-brain barrier, allowing your body to make much more efficient use of each dose compared to regular thiamine.

Today, thiamine and sulbutiamine are practically interchangeable, and we’ll be referring to them by either name throughout the article.

Sulbutiamine benefits

Beyond helping to prevent deadly diseases like beriberi, sulbutiamine offers a broad array of benefits for your body as well as your brain. It’s also used in clinical settings to supplement treatment for a broad variety of diseases and ailments from AIDS to canker sores.

As with all the B vitamins, thiamine aids in the conversion of carbohydrates, protein, and fats into glucose for energy production. These vitamins are critical for our liver, eyes, nails, and hair, and they also support brain and nervous system function.

It seems sulbutiamine may even be able to help treat a form of erectile dysfunction known as psychogenic erectile dysfunction. In a recent study, the majority of those who received sulbutiamine over 30 days experienced a marked reduction in their symptoms.

Not only is sulbutiamine beneficial for your overall health, but there are also some powerful nootropic benefits, associated with this supplement as well.

Thiamine may help increase our energy levels and focus while also protecting our brains against memory loss by preventing inflammation. The neurotransmitter acetylcholine (ACh) also depends on thiamine to function properly. ACh plays a vital role in cognition, memory, and learning functions.

Vitamin B1 is sometimes referred to as the anti-stress vitamin, which can fortify your body to better withstand stress. Research suggests that thiamine can also improve your mood and even help protect against anxiety or depression.

One such study on sulbutiamine supplementation concluded that the mood, reaction times, and energy levels of the test group were higher than that of the control group,

Those suffering from chronic fatigue may find that sulbutiamine supplementation is just as if not more helpful than another cup of coffee or energy drink. In a study of test subjects with chronic fatigue, patients who were given sulbutiamine supplements were less fatigued than those who received a placebo.

Memory issues appear to be related to low choline levels in the brain. Choline is necessary for the creation of ACh, and since ACh plays a role in memory formation, some researchers have hypothesized that those with more acetylcholine will have greater memory function. Much more research is needed on this link, but it’s promising to say the least.

What happens when you don’t have enough Thiamine?

Fortunately, most people in developed nations receive enough B1 from their diet alone, but in some cases, thiamine deficiency can lead to some serious side effects and health risks.

Diseases like beriberi, Wernicke-Korsakoff syndrome, or AIDS are all linked to thiamine deficiencies, and anyone who is suffering from these diseases is also at a heightened risk for having a B1 deficiency.

A deficiency can cause weight loss or anorexia, memory loss, confusion, muscle weakness, and even cardiovascular issues. Ensuring you’re getting enough thiamine is critical to your well-being, and it should be at the front of everyone’s mind.

A lack of thiamine also slows the production of ATP in the brain and reduces acetylcholine levels. These issues can cause issues with your short-term memory, comprehension ability, and even your perception.

Sulbutiamine dosage

Sulbutiamine is typically available in tablets, capsules, or powder. Many people will purchase sulbutiamine powder and make their own capsules at home, which is a great way to save money. Most sulbutiamine powders taste a bit disgusting on their own, so most people opt for tablets or capsules.

Recommended dosage ranges from 400-1000mg per day. Those taking higher doses should split the daily dose into two halves, with one being taken in the morning and the other in the afternoon. Since it does have some mild stimulating properties, taking it too late in the day may interfere with your ability to fall asleep.

Keep in mind that sulbutiamine is fat-soluble, and it should be taken with food to increase its absorption. Taking your dose with a spoonful of coconut oil, peanut butter, or olive oil is a great way to ensure that your dose is properly absorbed.

Sulbutiamine tolerance can become an issue, so those who take a sulbutiamine supplement daily will want to consider cycling their dosage to mitigate these issues. A popular cycle is five days on, followed by two days off.

Sulbutiamine side effects

As a synthetic analog of vitamin B1, sulbutiamine is entirely non-toxic, and it’s considered to be safe and well-tolerated by the body. Sulbutiamine side effects are quite rare, and usually, are only a factor with exceptionally high doses of sulbutiamine.

Side effects can include:

  • Difficulty sleeping
  • Headaches
  • Skin rashes
  • Mood swings

Difficulty sleeping is the most common side effect, and it can usually be alleviated by taking your dosage earlier in the day. While headaches are a common side effect, it’s often difficult to pinpoint the exact cause of a headache, and they can often be related to other aspects of your routine.

Skin rashes, especially if severe, are an indication that you’re taking way too high a dose of sibutramine. Reducing your dose may help mitigate this problem unless you’re exhibiting an allergic reaction.

Some people taking sulbutiamine have reported mood swings, especially those that deal with bipolar disorder. It may be best to avoid sulbutiamine for this reason if you’re currently being treated for bipolar disorder.

Sulbutiamine stacks

Most neurohackers are always looking for ways to maximize the positive effects of different nootropics, and sulbutiamine is a popular component of several stacks which may help you achieve even greater benefits than you’d see if you took them individually.

One popular stack, sulbutiamine, huperzine A, and alpha GPC may help slow ACh decomposition while providing plenty of additional choline. This stack is purported to boost memory power and capacity while also enhancing concentration. This stack is taken once or twice daily, and it’s comprised of:

Many find that the racetam family of nootropics stacks well with sulbutiamine, and provides a boost to energy levels and mood, while also aiding with concentration, comprehension, and cognition. Depending on the intensity of the effect you’re looking for, you can choose to include Piracetam, Aniracetam, or Phenylpiracetam in your stack. Taken once or twice each day, this stack is made up of:

Where to buy sulbutiamine

At, you can buy Sulbitiamine in a jar of 60x200mg capsules. We also sell Alpha-GPC if you would like to include it in your stack.

All of our products are quality tested once after manufacturing, and then undergo a stringent process of quality assurance by an independent third-party lab. You can find a link to our Certificate of Authenticity on the Sulbutiamine product page. We test for identity, purity, and use FTIR and HPLC to make sure the sample does not contain heavy metals.

Our customers get free shipping on orders over $70 in the US and $200 for international orders. If you buy 2 or more jars, you get a 5% and 10% discount. We offer a money-back guarantee 90 days after you buy any of our products.

We only use vegetable capsules suitable for vegans.


With a long record of research and a litany of different practical uses for the health of your body and brain, sulbutiamine may be one of the best nootropics to take for your overall health.

Before you even consider the brain benefits, the fact that sulbutiamine is critical to so many of the different processes and systems involved in your health is reason enough to add it to your routine. From your muscles to your nervous system, sulbutiamine can help you function at the proper level.

If you’re looking for a nootropic that may be able to boost your mood and energy level, support memory function, learning, and cognition and also providing a neuroprotective effect, you don’t even need your brain to be functioning in top shape to know that sulbutiamine is a wise choice.