Noopept Dosage: How to Optimally Dose This Popular Nootropic

With a wide range of benefits and a low price tag, it’s no wonder that noopept is a go-to nootropic for many in the community. People take noopept as a cognitive enhancer that provides a powerful boost reminiscent of the racetam family of nootropics, which are also quite popular.

Today, we’ll take a closer look at some important Noopept information, especially with regard to the best Noopept dosage for the specific benefits you’re hoping to realize.

What is Noopept?

In the 1950s, scientists developed piracetam as a potential treatment for degenerative brain diseases like dementia or Alzheimer’s, and certain forms of epilepsy. With further research, it became evident that piracetam may possess cognition-enhancing and neuroprotective effects as well, suggesting the potential for a variety of different uses.

Over the years, many variants of piracetam have been created, and the racetam family of nootropics is a favorite among neurohackers everywhere. In the mid-90s, scientists developed N-Phenylacetyl-l-prolylglycine ethyl ester, which is more commonly known as Noopept.

As a descendant of the racetams, noopept works quite similarly to piracetam, but it’s even more powerful, and it’s also one of the most affordable nootropics on the market.

How does Noopept work?

Much more human study is needed before we can conclusively comment on the mechanism of action for Noopept. With regular intake, noopept appears to increase nerve growth factor and brain-derived neurotrophic factor, which may play key functions in areas like learning, cognition, focus, attention, and memory formation and retention.

Once Noopept crosses the blood-brain barrier, it modulates your NMDA and AMPA receptors and aids in the transmission of acetylcholine. It also inhibits glutamate production, which helps maintain optimal levels of glutamate in the brain.

Researchers hypothesize that the proper flow of glutamate and acetylcholine within the brain has a neuroprotective effect that may also be able to improve cognition, learning, recall, mood, and learning.

Overdose of glutamate can result in the death of neurons, while too little can result in learning and memory issues when these levels are out of line, ACh levels, and brain plasticity decrease. By working to keep these levels in order, Noopept may be able to protect your brain from the inherent damage that comes with age while also improving mental function.

Why do people take Noopept?

Neurohackers are always looking to get an edge and optimize their brain function, so it’s no wonder so many of them turn to Noopept, as it can provide a variety of different benefits.

Research indicates that a dose of Noopept may increase focus and attention, making it a popular study aid and a great way to keep your edge when you’re engaged in complex tasks at work.

Noopept’s effect on NGF and BDNF may help with long-term potentiation, and users claim to be able to more readily recall memories with greater detail than before.

Thanks to its antioxidant effect and the anti-inflammatory action it provides, Noopept is also a neuroprotective agent that helps purge free radicals from brain cells while also protecting against neurodegeneration.

Noopept dosage

As a powerful cognitive enhancer, the proper Noopept daily dosage is much lower than what you may be accustomed to if you’re used to using racetams. With Noopept, lower dosages can produce impressive cognitive benefits.

Noopept is available in tablet, power, and even liquid form. Those looking for the quickest effect may want to take a liquid dosage sublingually to provide the quickest effects. Many people find that unnecessary since Noopept goes to work quite quickly once ingested.

The accepted Noopept dosage is 10mg, taken once or twice daily. Noopept is water-soluble and depending on your unique attributes, like your height, weight, and age, you may find that increasing your dosage to 30-40mg per day is ideal.

When dosing, start with the minimum effective dose, and take as little as you need to produce the desired effects. Until we know more about how prolonger Noopept usage affects the liver, it’s recommended that you do not take Noopept for longer than three months at a time.

The effects of Noopept may diminish over time as your body develops a tolerance. To combat this effect, you may consider cycling your dosage. A popular cycle is five days on, followed by two days off.

Those who are taking Noopept twice daily should take their second dose with lunch and avoid taking it later in the day, as this may lead to issues with sleeplessness.

Dosage notes for beginners

Whether you’re using Noopept or any other nootropic, it’s important that you exercise caution when incorporating new dietarysupplements into your routine. If you experience any side effects when taking Noopept, decrease, or discontinue use altogether.

Always follow recommended dosage guidelines, and consider getting started with half the recommended dose and ramping up from there so you can learn how your body reacts to Noopept in a more controlled way.

If you’ve used a racetam before, keep in mind that while the effect may be similar to Noopept, the Noopept dosage is much smaller than a typical dosage of a racetam. Where users may take 1,000mg of piracetam in a dose, a typical dose of Noopept is 10mg.

How to take Noopept

Noopept is water-soluble, and some people find that taking it with a meal aids with absorption and metabolization, but that shouldn’t be necessary for your body to properly absorb Noopept. If properly absorbed, the maximum amount of Noopept will become bioavailable for use by the brain.

Since Noopept may increase focus and alertness, it’s best to take your dose in the morning. If you take a second dose, try to do it in the early afternoon to reduce the chances that it will keep you up when you’re trying to sleep.

Popular Noopept stacks

While many people rely on Noopept alone to deliver all the cognitive and memory-related benefits they need, it does stack quite well with other supplements, and it’s a popular component in many nootropic stacks.

Noopept, Piracetam, and Choline are the most popular stack. The idea behind this stack is that while they produce similar effects, noopept and piracetam work on different neurotransmitters. So, stacking the two may have a synergistic effect. The addition of choline may influence the effectiveness of piracetam.

Piracetam uses choline in its processes, and decreased choline levels may cause headaches, which are one of the few common side effects people complain about with piracetam. The choline in this stack should protect against any headaches.

This stack is taken once or twice daily, and one dose is comprised of:

Another popular stack is comprised of Noopept, Aniracetam, Sulbutiamine, and Alpha GPC.

This stack is designed to produce similar benefits to the stack above. However, aniracetam is a more powerful derivative of piracetam. Sulbutiamine is also added for it’s powerful anti-stress and mood-enhancing benefits.

This stack is ideal for those looking to improve their focus, attention, cognitive function, and memory while also providing a relaxed calm that promotes productivity. Users take this combo once or twice daily, and it’s made up of:

The nootropic community is an excellent resource for learning which supplements stack well together and which don’t, so while these stacks are a great way to get your feet wet, there’s many more different combinations and supplements you may want to consider as you learn more about stacking Noopept.

Potential Noopept side effects

Based on limited studies and a broad range of anecdotal evidence, Noopept seems to be extremely well-tolerated, and it presents very few side effects. Those who do experience side effects complain of:

  • Headaches
  • Irritability
  • Dizziness
  • Anxiety
  • Sleeplessness
  • Nausea

The most common side effect is sleeplessness, and they’re also the easiest side effect to avoid. If you find that Noopept makes it difficult for you to fall asleep, start taking your dosage earlier in the day, or consider eliminating the afternoon dose altogether.

Side effects are more common at higher doses and may be an indication that you should reduce your Noopept dosage.

Based on what we know, there don’t appear to be any dangerous drug interactions with Noopept, although women who are pregnant or nursing, and those with high blood pressure should avoid taking Noopept. However, if you find that Noopept causes side effects with any of the other medication or supplements you may be taking, stop taking it right away.

In studies and user reports, there doesn’t appear to be any risk of dependence, or withdrawal symptoms associated with taking Noopept.


Noopept is one of the most well-loved nootropics in the world, and it may be able to realize some powerful cognitive benefits that can help you get an edge in your everyday life. With far-reaching benefits that may improve cognition, focus, memory, and learning, very few side effects, and a low price per dose, Noopept may be the perfect nootropic to add to your regimen.

When you’re first getting started with Noopept, begin with a low dose before graduating to higher doses, and reduce your dosage if you’re experiencing any side effects.