Coluracetam: Everything You Need to Know

Learning about Coluracetam isn’t easy. Information is scarce. Is it accurate? Trustworthy? We feel your pain, so we decided to do a lot of the heavy-lifting ourselves.

In this guide, you’ll learn all about Coluracetam recommended dosage, side effects, benefits, and you’ll also learn how Coluracetam is easy to use sublingually.

One of the first things to know about Coluracetam is how it began. Coluracetam is a nootropic that was originally developed in Japan by the Mitsubishi Tanabe Pharma Corporation. Coluracetam was originally designed to help treat Alzheimer’s disease and has also been considered as a viable option to treat MDD (major depressive disorder).

Coluracetam is typically sought after by those who wish to improve memory, learning, brain function, and to help treat anxiety and schizophrenia. There has been a wide array of studies conducted on Coluracetam’s effect on rats. However, there is a glaring lack of clinical trials involving humans. There are, however, an abundance of comments and reviews on social media and Reddit which we’ll discuss later in this guide.

According to this article on Wikipedia, a company based out of California named Brain Cells Inc. has studied Coluracetam and determined that Coluracetam may be a potential treatment option for major depressive disorder and generalized anxiety disorder.

Coluracetam has been used in rodent studies to research if the chemical can improve cognitive function. This study, published in the Journal of Neural Transmission reveals the fascinating ability of toxin-exposed rats to improve their learning impairment after given a single dosage of Coluracetam orally. Such a feature implies that Coluracetam is capable, to some extent, of healing certain damage to nerve cells.

According to another study published in the Journal of Neural Transmission, Coluracetam works by enhancing HACU, or high-affinity choline uptake. HACU is a step of acetylcholine synthesis, an important neurotransmitter in humans and other animals.

Quick facts about Coluracetam

  • Created by Mitsubishi Tanabe Pharma Corporation in Japan to treat Alzheimer’s disease.
  • Is designed to improve cognitive function.
  • Has shown promising results in improving the brain function of rats.
  • A nootropic found in the racetam family.
  • Also known as BCI-540, or previously MKC-231.
  • The chemical formula of C₁₉H₂₃N₃O₃ (Source).

Coluracetam Dosage

Please remember that you should always consult with your favorite doctor, medical advisor, or healthcare provider before experimenting with Coluracetam or any nootropic. Also, be sure to follow the instructions provided by your preferred nootropic provider.

Also remember that your unique body composition, your health, your metabolism, and medications you’re currently taking may affect how Coluracetam or any other nootropic interacts with your body. Therefore, it’s important to seek the council of your preferred medical council before starting any new nootropic or medicine.

If you’re new to Coluracetam, start with a tiny dosage! As you learn how the nootropic impacts your bodily function, you can increase dosage if you wish. It’s important to remember that some users on social media have reported fatigue when experimenting with Coluracetam in large doses, so always remember to test in small doses.

Based on our research and our studying of Coluracetam user reviews, here is the common dosage: 50 – 200 mg daily.

Coluracetam Side Effects

After conducting much research, it’s difficult to find any Coluracetam clinical studies that involve negative side effects. Conclusive evidence regarding any negative side effects for Coluracetam is therefore difficult to report. But maybe you’re wondering what to expect? When you’re experimenting with Coluracetam or any other nootropic, be sure to pay very close attention to how your body reacts.

Regarding Coluracetam side effects, there don’t seem to be many documented cases. However, please be advised that just because there are not many documented cases of Coluracetam side effects, doesn’t mean that it’s perfectly safe under all situations.

Typically, users seek Coluracetam if they wish to improve their short and long-term memories, cognitive function, ability to recall vocabulary, and overall mental clarity. People from all over the world across all walks of life may benefit from having improved cognitive function, so the benefits that Coluracetam offers may have a wide appeal.

If you decide to experiment with Coluracetam, you may find that your memory improves, that you have better memory, and some users have also reported experiencing less anxiety. For a much closer look into how some users are describing their Coluracetam use, check out this helpful Coluracetam discussion on Reddit.

Coluracetam may affect your body in the following ways:

  • Increased clarity.
  • Alertness.
  • Drowsiness.

Coluracetam Benefits

Remember that Coluracetam was originally developed to help with the treatment of Alzheimer’s disease. Ultimately the development process evolved to studying how Coluracetam can potentially help to treat various mental ailments such as depression, and anxiety.

The wide array of studies showcased on this Coluracetam Wikipedia article would suggest that Coluracetam has a wealth of existing benefits that should excite anyone who is looking to improve their overall brain function. Let’s discuss some of the many benefits that one may discover as a result of those featured studies.

Arguably the single biggest benefit of Coluracetam is the improved memory and brain function in rats exposed to a damaging nerve toxin. This one feature and benefit makes Coluracetam worthy of note. The study reveals the promising potential for Coluracetam and for anyone who wishes to improve or study the future improvement of brain function, learning, and memory.

Another fascinating benefit of Coluracetam is that the nootropic may help to improve major depressive disorder or generalized anxiety disorder. Either of these mental afflictions can be crippling, and the potential for Coluracetam to address and treat symptoms of depression, or anxiety is another tremendously promising benefit.

Here are some of the crushing symptoms of major depressive disorder:

  • Low self-esteem.
  • Loss of interest.
  • Low energy.
  • Emotional pain.

Here are some of the crushing symptoms of anxiety:

  • Excessive worry.
  • Restlessness.
  • Trouble sleeping, or drowsiness.
  • Irritability.
  • Trembling.

You’ll probably agree that anxiety and depression are both significantly problematic mental disorders, and the potential for Coluracetam to alleviate symptoms are probably worthy of additional clinical trials.

Coluracetam Sublingual

Two of the most popular ways to take Coluracetam are orally and sublingually. Administering Coluracetam sublingually typically involves dropping a liquid under your tongue and letting it dissolve through your skin. Taking Coluracetam or any nootropic sublingually allows the Coluracetam to go directly into your bloodstream, which may allow a faster effect than ingesting the nootropic orally.

It’s also possible that when you administer Coluracetam sublingually that the effects feel stronger.

Of course, always remember that your brain chemistry and body is unique! For that reason, when experimenting with Coluracetam sublingually, it’s always important to experiment with different dosages to see how you feel. The best advice anyone can give you when experimenting with Coluracetam or any nootropic is to start at a very low dosage.

Also remember that some users on Reddit and other social platforms report using much smaller doses than others, and that depending upon where you purchase your Coluracetam solution, the dosage of each dropper may vary. Pay very close attention to the strength of any Coluracetam solutions that you purchase and pay very close attention to the dosage instructions.

Pay very close attention to these variables when purchasing a Coluracetam solution:

  • The overall size of the bottle.
  • Amount of mg per dosage/dropper.
  • Be sure to test in very small dosages!


If you’re frustrated because you’re suffering from anxiety, depression, or if you want to try improving your cognitive function, then Coluracetam might be worthy of experimentation.

It’s also important to remind yourself that you’re not alone if you’re suffering from depression. The sad truth is that depression is shockingly common around the world, and especially in the United States. A study published by the CDC states that roughly 8.1% of American adults (aged 20 or over) experienced depression in 2013-2016.

Out of the 8.1% of adults suffering from depression, a whopping 80% also had trouble at home, work, or in their social life as a direct result of their depression.

The news gets even worse because unfortunately, the percentage of adults with depression doesn’t seem to be decreasing over time. Therefore, depression is a huge problem in America, and it’s a problem that doesn’t seem to be going away.

Maybe you’re currently experiencing depression, and you’re wondering if Coluracetam is right for you? Hopefully, this guide has shown you how Coluracetam offers a glimpse of hope for those who suffer from depression and may also offer a wide array of benefits for your mind.

Unfortunately, it’s difficult to conclude whether Coluracetam can help your depression, your anxiety, or your ability to think more clearly. One thing is for sure, though, Coluracetam has indeed showcased promising results in clinical trials involving rats and improved brain function, and many users around the world look to Coluracetam for increased mental clarity.

Remember that experimenting with Coluracetam may very well help your depression, but until you test and experiment, it’s almost impossible to tell how your body is going to react. That’s because your body’s chemistry is unique.

Always be sure to seek the guidance of your preferred doctor, medical professional, or healthcare provider to discuss treatment options for any depression or anxiety. While talking with your doctor, ask if Coluracetam might be a feasible option for you.