How strong is the evidence for Galantamine?

The overall grade on file is A (strong). 2 claimed benefits are graded separately in the table above. 1 of the benefit grades of A have no verified study cited yet. The entry cites 1 study.

What dose of Galantamine has been studied?

The range on file is 4-12 mg (1-2 doses). It describes doses used in research, not a recommendation.

How long does Galantamine take to work and how long does it last?

Listed onset: about 60 minutes. Listed half-life: about 7 hours. Individual metabolism varies.

What are the side effects of Galantamine?

Recorded side effects: Nausea / vomiting (common), Bradycardia (uncommon). Safety score 3/5.

Galantamine

Also called Reminyl, Razadyne

Galantamine is a prescription acetylcholinesterase inhibitor first isolated from snowdrop bulbs. Trials have examined it mainly for mild-to-moderate Alzheimer's disease.

Evidence: AStrong evidence
Studied dose: 4-12mg
Safety score
Verified references: 1 study

How entries are graded Report an error in this entry Corrections policy

How it is thought to work

Galantamine reversibly inhibits acetylcholinesterase and also acts as an allosteric potentiator of nicotinic acetylcholine receptors. It crosses the blood-brain barrier.

Availability

Galantamine is prescription-only, legally restricted, or not sold as a lawful dietary supplement in many jurisdictions, so we do not list places to buy it. Legal status of Galantamine by country.

What the studies found

2 benefits are graded: 1 strong (A), 1 limited (C). 1 of the A grades has no verified study cited yet.

Claimed benefit	Grade	Basis
Mild-to-moderate Alzheimer's	A	Graded A, but no verified study is cited for this claim yet.Multiple RCTs.
Lucid dreaming (anecdotal)	C	Popular for REM-stage dream induction.

Each benefit is graded on its own; a substance can have strong evidence for one effect and little for another. What the grades mean.

Dose and timing

Studied dose range

Doses used in the research on file, taken as 1-2 doses. Not a recommendation.

Listed time course

Logarithmic time scale. Individual metabolism varies.

Galantamine dosage record in full

Safety and interactions

Recorded side effect	How often	Severity
Nausea / vomiting	common	moderate
Bradycardia	uncommon	moderate

Side effects in detail Interaction checker

History

Soviet pharmacologist Mashkovsky isolated galantamine from the bulbs of the Caucasian snowdrop (Galanthus woronowii) in the 1950s. It was used in Eastern Europe for myasthenia gravis and polio before being studied for Alzheimer's disease. Janssen launched it as Reminyl (later Razadyne) in the early 2000s.

References

Galantamine for lucid dreaming and REM sleep (LaBerge). 2018. PubMed 30089135

Reader reviews

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No reader reviews have been published for this substance yet.

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Galantamine: quick answers

How strong is the evidence for Galantamine?: The overall grade on file is A (strong). 2 claimed benefits are graded separately in the table above. 1 of the benefit grades of A have no verified study cited yet. The entry cites 1 study.
What dose of Galantamine has been studied?: The range on file is 4-12 mg (1-2 doses). It describes doses used in research, not a recommendation.
How long does Galantamine take to work and how long does it last?: Listed onset: about 60 minutes. Listed half-life: about 7 hours. Individual metabolism varies.
What are the side effects of Galantamine?: Recorded side effects: Nausea / vomiting (common), Bradycardia (uncommon). Safety score 3/5.

Compared with other substances

Show 1

Comparison	Grade	Class
Galantamine vs Alpha-GPC	A	Cholinergic

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