Fisetin
Flavonol found in strawberries, apples and onions, studied as a senolytic (an agent that clears senescent cells), mostly in animals.
- Evidence
- BModerate evidence
- Studied dose
- 100-500mg
- Safety score
- Verified references
- None yet, sources being re-verified
How it is thought to work
Fisetin is reported to induce apoptosis selectively in senescent cells. It also inhibits PI3K/AKT/mTOR signalling and has antioxidant activity.
Where to buy Fisetin
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| Vendor | Product | Size | Price | Per unit | Buy |
|---|---|---|---|---|---|
| Amazon |  Life Extension Bio-Fisetin, Cellular and Cognitive Health... | - | On Amazon | - | Check price on Amazon Ad |
| iHerb | Nutricost, Fisetin, 100 mg , 60 Capsules | - | about $21.95 at iHerb (as of 24 September 2026) | - | Shop Ad |
| iHerb | Life Extension, Bio-Fisetin, 30 Vegetarian Capsules | - | about $11.25 at iHerb (as of 24 September 2026) | - | Shop Ad |
| iHerb | Doctor's Best, Fisetin , 100 mg, 30 Veggie Caps | - | about $22.99 at iHerb (as of 24 September 2026) | - | Shop Ad |
What the studies found
| Claimed benefit | Grade | Basis |
|---|---|---|
| Senolytic activity in vivo | B | Source being re-verified |
| Cognitive aging (animal models) | C | Source being re-verified |
Each benefit is graded on its own; a substance can have strong evidence for one effect and little for another. What the grades mean.
Dose and timing
Doses used in the research on file, taken as 1 dose (cycle). Not a recommendation.
Safety and interactions
| Recorded side effect | How often | Severity |
|---|---|---|
| Mild blood-thinning | uncommon | mild |
History
Yousefzadeh 2018 identified its senolytic activity while screening flavonoids. Currais 2018 reported reduced cognitive decline in an Alzheimer mouse model. Human senolytic trials remain limited.
Reader reviews
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Sign in to reviewFisetin: quick answers
- How strong is the evidence for Fisetin?
- The overall grade on file is B (moderate). 2 claimed benefits are graded separately in the table above.
- What dose of Fisetin has been studied?
- The range on file is 100-500 mg (1 dose (cycle)). It describes doses used in research, not a recommendation.
- What are the side effects of Fisetin?
- Recorded side effects: Mild blood-thinning (uncommon). Safety score 4/5.
Compared with other substances
Show 6Hide
| Comparison | Grade | Class |
|---|---|---|
| Fisetin vs Quercetin | B | Neuroprotective |
| Fisetin vs Curcumin (Turmeric) | B | Neuroprotective |
| Fisetin vs Magnesium L-Threonate | B | Neuroprotective |
| Fisetin vs Melatonin | A | Neuroprotective |
| Fisetin vs NMN | B | Neuroprotective |
| Fisetin vs Omega-3 (DHA/EPA) | A | Neuroprotective |
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